PHARMACEUTICS
Year : 2009  |  Volume : 1  |  Issue : 1  |  Page : 24-27

Development and evaluation of gelatin microspheres of tramadol hydrochloride


Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Viswavidyalayam (Women's University), Tirupati, Andhra Pradesh -517 502, India

Correspondence Address:
J B Jeevana
Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Viswavidyalayam (Women's University), Tirupati, Andhra Pradesh -517 502
India
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Crossref citations3

DOI: 10.4103/0975-1483.51871

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To develop formulations for effective management of chronic pain without side effects associated with NSAIDs and COX-2 antagonists, Tramadol hydrochloride, an opioid antagonist, was encapsulated within Gelatin microspheres for controlled delivery for longer periods. The microspheres were prepared using a single emulsion technique and were investigated. Tramadol hydrochloride could be encapsulated into Gelatin microspheres with an entrapment efficiency of 97.2%. Spherical, transparent, and free-flowing microspheres were obtained. Scanning electron microscopy revealed the spherical structures under the magnification of 200 m. The FTIR and DSC analysis indicated the stability and compatibility of the drug in gelatin microspheres. The microspheres were in the suitable particle size range of 20 to 160 m. The drug was released continuously for a period of 12 hrs with a maximum release of 99.79%.


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