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INVITED ARTICLE
Year : 2009  |  Volume : 1  |  Issue : 1  |  Page : 6-12

Microcrystalline cellulose as a versatile excipient in drug research


Jamia Hamdard, Department of Pharmaceutics, Faculty of Pharmacy, Hamdard Nagar, New Delhi-110 062, India

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J Ali
Jamia Hamdard, Department of Pharmaceutics, Faculty of Pharmacy, Hamdard Nagar, New Delhi-110 062
India
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DOI: 10.4103/0975-1483.51868

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Microcrystalline cellulose (MCC) has emerged as the most resourceful excipient of all times in drug research. Thanks to its profusion in terms of grades available for different needs and its physical properties that support a variety of functionality requirements especially for the most frequently used unit dosage forms. MCC can be used as a bulking agent, disintegrant, binder, lubricant, and glidant besides being a stability enhancer and a secondary suspending agent. It can be used in direct compression of most drugs and saves material, capital, equipment, and labor. Its ever increasing applications in drug research include its utility in immediate release (tablets and liquids) dosage forms, sustained release dosage forms (multiparticulates and matrix tablets), topical preparations, oral liquids, organoleptic enhancements as in chewable and mouth dissolving tablets, anti-reflux, and nutraceuticals. The review discusses these applications in sufficient detail citing examples and investigating the justifications for such functions.


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