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PHARM ANALYSIS
Year : 2009  |  Volume : 1  |  Issue : 4  |  Page : 354-358

Derivative spectrophotometry method for simultaneous estimation of rupatadine and montelukast in their combined dosage form


1 Department of Pharmaceutical Chemistry, M.P. Patel College of Pharmacy, Jeevanshilp Campus, Kapadwanj, Dist-Kheda-387 620, Gujarat, India
2 Department of Pharmaceutical Chemistry, A.R. College of Pharmacy, Vallabh Vidyanagar, Gujarat, India

Correspondence Address:
P G Patel
Department of Pharmaceutical Chemistry, M.P. Patel College of Pharmacy, Jeevanshilp Campus, Kapadwanj, Dist-Kheda-387 620, Gujarat
India
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DOI: 10.4103/0975-1483.59327

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This study describes the development and validation for the simultaneous estimation of rupatadine and montelukast by the first-order derivative UV spectroscopy method. The quantification was achieved by the first-order derivative spectroscopy method at 273.46 nm and 297.27 nm over the concentration range of 5-25 µg/ml for estimation of rupatadine and montelukast in a combined tablet formulation. Procedure does not require prior separation of components from the sample. Rupatadine and montelukast were determined at 15 µg/ml with a mean recovery of 99.59 + 0.225 and 99.21 + 0.76, respectively. Calibration curves were linear with a correlation coefficient of 0.9994 and 0.9992 for rupatadine and montelukast, respectively. The relative standard deviation was found to be <2.0%. The present result shows that the proposed method can be successfully used for simultaneous determination of the drug content in marketed formulations.


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