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Year : 2010  |  Volume : 2  |  Issue : 1  |  Page : 79-84

Stability indicating high-performance liquid chromatography method for the estimation of artemether in capsule dosage forms

1 Department of Pharm. Sciences, B.R. Nahata College of Pharmacy, Mhow-Neemuch Road, Mandsaur (M.P) - 458 001, India
2 L.M. College of Science and Technology, Pharmacy wing, Shastri Nagar, Sector A, Jodhpur (Rajasthan), India

Correspondence Address:
A Shrivastava
Department of Pharm. Sciences, B.R. Nahata College of Pharmacy, Mhow-Neemuch Road, Mandsaur (M.P) - 458 001
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DOI: 10.4103/0975-1483.62220

PMID: 21331197

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A new simple, sensitive, precise, and accurate high-performance liquid chromatography (HPLC) method of analysis for artemether both as a bulk drug and in capsule formulations was developed and validated. The method employed mobile phase acetonitrile (ACN) and buffer in the ratio 65:35 of pH 6.5 adjusted with tryethylamine. The linear regression analysis data for the calibration plots showed good linear relationship with r2 = 0.9996 in the concentration range 250-750 µg/ml. The mean value slope and intercept were 9355.5 and -93.5, respectively. The method was validated for precision, accuracy, and recovery studies. Limit of detection (LOD) and Limit of quantitation (LOQ) for artemether were found to be 21.83-750 µg/ml, respectively. The method has been successfully applied in the analysis of marketed capsule formulations. The presented method was found to be reliable to separate all the degradents from all the stress conditions with resolution of more than 1.5 showing that it is a stability indicating method.

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