Home | About JYP | Editorial board | Search | Current Issue | Archives | Instructions | Contact us |   Login 
Journal of Young Pharmacists Journal of Young Pharmacists
Search Article 
Advanced search 
Year : 2010  |  Volume : 2  |  Issue : 1  |  Page : 95-100

A Pharmacovigilance Study in Medicine Department of Tertiary Care Hospital in Chhattisgarh (Jagdalpur), India

1 Department of Pharmacology, Government Medical College, Jagdalpur, Chhattisgarh, India
2 Department of Medicine, Government Medical College, Jagdalpur, Chhattisgarh, India
3 Department of Pharmacology, Government Medical College, Rewa, MP, India
4 Department of Anatomy, Government Medical College, Jagdalpur, Chhattisgarh, India

Correspondence Address:
H Singh
Department of Pharmacology, Government Medical College, Jagdalpur, Chhattisgarh
Login to access the Email id

DOI: 10.4103/0975-1483.62222

PMID: 21331200

Get Permissions

The aim of the present study was to observe adverse drug reactions (ADRs) with respect to polypharmacy at tertiary care centre at Bastar, Jagdalpur (Government Medical College, Jagdalpur). A prospective, observational evaluation of the ADRs conducted over a period of 6 months in Department of Medicine in Government Medical College, Jagdalpur. During the study period, a total of about 4850 patients visited the OPD and inpatient ward of medicine department, and 154 ADRs events were reported. Out of 154 reports that were identified, a higher percentage of ADRs in females (51.29%) was observed as compared to males (48.7%). Of the 154 ADRs, 76 (49.35%) were found to be mild, 55 moderate (35.71%), and 23 severe (14.93%). A total of 99 (64.28%) ADRs were observed in patients receiving four or more medications concurrently. Conversely 55 (35.71%) ADRs were detected in patients using three or less medicines. The largest number of reports was associated with antimicrobial therapy (28.57%), followed by antihypertensive (24.02%) and antidiabetics (14.28%). Among the affected organ systems, gastrointestinal ADRs constituted a major component (39.61%) followed by skin reactions (28.57%). On causality assessment, nearly 36.36% ADRs were considered as probable, 31.16% possible, and 9.74% could not be categorized and were placed under unassessable. Expected, limited ADR are permissible in normal clinical setting, but the present study focuses on the result showing increased and amplified ADR associated with the polypharmacy practices, which may be curtailed with rational drug prescribing habit.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded136    
    Comments [Add]    

Recommend this journal