PHARMACEUTICAL ANALYSIS
Year : 2010  |  Volume : 2  |  Issue : 2  |  Page : 190-195

Comparative study of RP-HPLC and UV spectrophotometric techniques for the simultaneous determination of amoxicillin and cloxacillin in capsules


Department of Analytical Chemistry and Toxicology, Hanoi University of Pharmacy 13-15 Le Thanh Tong, Hanoi, Vietnam

Correspondence Address:
Vu D Hoang
Department of Analytical Chemistry and Toxicology, Hanoi University of Pharmacy 13-15 Le Thanh Tong, Hanoi
Vietnam
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DOI: 10.4103/0975-1483.63168

PMID: 21264124

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Reversed-phase HPLC and UV spectrophotometric techniques using water as solvent have been developed and validated for the simultaneous determination of amoxicillin and cloxacillin in capsules. For both techniques, the linearity range of 60.0-140.0 ΅g/mL was studied. The spectrophotometric data show that non-derivative techniques, such as absorbance ratio and compensation, and ratio spectra first-order derivative could be successfully used for the co-assay of amoxicillin and cloxacillin. Based on the statistical comparison of spectrophotometric and chromatographic data, the interchangeability between HPLC and UV spectrophotometric techniques has been suggested for the routine analysis.


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