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PHARMACEUTICS
Year : 2010  |  Volume : 2  |  Issue : 3  |  Page : 240-246

Formulation and characterization of patient-friendly dosage form of ondansetron hydrochloride


S.K.B. College of Pharmacy, New Kamptee, Dist. Nagpur, Maharashtra, India

Correspondence Address:
P K Bhoyar
S.K.B. College of Pharmacy, New Kamptee, Dist. Nagpur, Maharashtra
India
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DOI: 10.4103/0975-1483.66796

PMID: 21042478

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Ondansetron hydrochloride is an intensely bitter antiemetic drug used to treat nausea and vomiting following chemotherapy. The purpose of the present work was to mask the taste of ondansetron hydrochloride and to formulate its patient-friendly dosage form. Complexation technique using indion 234 (polycyclic potassium with carboxylic functionality) and an ion-exchange resin was used to mask the bitter taste and then the taste-masked drug was formulated into an orodispersible tablet (ODT). The drug loading onto the ion-exchange resin was optimized for mixing time, activation, effect of pH, mode of mixing, ratio of drug to resin and temperature. The resinate was evaluated for taste masking and characterized by X-ray diffraction study and infrared spectroscopy. ODTs were formulated using the drug-resin complex. The developed tablets were evaluated for hardness, friability, drug content, weight variation, content uniformity, friability, water absorption ratio, in vitro and in vivo disintegration time and in vitro drug release. The tablets disintegrated in vitro and in vivo within 24 and 27 s, respectively. Drug release from the tablet was completed within 2 min. The obtained results revealed that ondansetron HCl has been successfully taste masked and formulated into an ODT as a suitable alternative to the conventional tablets.


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