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PHARM CHEMISTRY
Year : 2010  |  Volume : 2  |  Issue : 3  |  Page : 273-279

Synthesis, characterization, and biological evaluation of benzimidazole derivatives as potential anxiolytics


1 Department of Pharmaceutical Chemistry, Mallareddy College of Pharmacy, Dhullapally Village, Hyderabad - 500 014, India
2 Department of Pharmacology, Joginpally B.R Pharmacy College, Yenkapally (P.O), Moinabad (Mandal), Ranga Reddy (Dist), Andhra Pradesh, India

Correspondence Address:
D T Nannapaneni
Department of Pharmaceutical Chemistry, Mallareddy College of Pharmacy, Dhullapally Village, Hyderabad - 500 014
India
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DOI: 10.4103/0975-1483.66809

PMID: 21042485

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The synthesized benzimidazoles compounds were prepared from the condensation reaction between o-Phenylenediamine and various carbonyl compounds, in the presence of ammonium chloride as a catalyst. Ammonium chloride is a commercial and environmentally benign catalyst. The yield of all benzimidazole derivatives was found to be in the range of 75 - 94%. The purity of the compounds was ascertained by melting point and TLC. The synthesized compounds were characterized by using IR, 1 H NMR, and MASS spectral data together with elemental analysis. The synthesized benzimidazole compounds were screened for acute and chronic anti-anxiety activity in Wistar rats by using an elevated plus maze model with standard Diazepam. The synthesized compounds Z B , Z E , Z F , Z G , and Z H showed potent anti-anxiety activity when compared to the standard Diazepam. The compound Z H exhibited a higher anti-anxiety activity when compared to other prepared benzimidazoles. The results were subjected to statistical analysis by using one-way ANOVA followed by the Tukey-Kramer test, to calculate the significance.


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