| PHARMACEUTICS |
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| Year : 2011 | Volume
: 3
| Issue : 4 | Page : 275-283 |
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Formulation and optimization of mucoadhesive nanodrug delivery system of acyclovir
UV Bhosale, V Kusum Devi, N Jain
Department of Pharmaceutics, Al Ameen College of Pharmacy, Near Lalbagh Main Gate, Hosur Road, Bangalore 560 027, India
Correspondence Address:
U V Bhosale
Department of Pharmaceutics, Al Ameen College of Pharmacy, Near Lalbagh Main Gate, Hosur Road, Bangalore 560 027
India
DOI: 10.4103/0975-1483.90236
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Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infections, with an oral bioavailability of only 10-20% [limiting absorption in gastrointestinal tract to duodenum and jejunum] and half-life of about 3 h, and is soluble only at acidic pH (pKa 2.27). Mucoadhesive polymeric nanodrug delivery systems of acyclovir have been designed and optimized using 2 3 full factorial design. Poly (lactic-co-glycolic acid) (PLGA) (50:50) was used as the polymer along with polycarbophil (Noveon AA-1) as the mucoadhesive polymer and pluronic F68 as the stabilizer. From the preliminary trials, the constraints for independent variables X 1 (amount of PLGA), X 2 (amount of pluronic F68) and X 3 (amount of polycarbophil) have been fixed. The dependent variables that were selected for study were particle size (Y 1 ), % drug entrapment (Y 2 ) and % drug release in 12 h (Y 3 ). The derived polynomial equations were verified by check point formulation. The application of factorial design gave a statistically systematic approach for the formulation and optimization of nanoparticles with the desired particle size, % drug release and high entrapment efficiency. Drug: Polymer ratio and concentration of stabilizer were found to influence the particle size and entrapment efficiency of acyclovir-loaded PLGA nanoparticles. The release was found to follow Fickian as well as non-Fickian diffusion mechanism with zero-order drug release for all batches. In vitro intestinal mucoadhesion of nanoparticles increased with increasing concentration of polycarbophil. These preliminary results indicate that acyclovir-loaded mucoadhesive PLGA nanoparticles could be effective in sustaining drug release for a prolonged period. |
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