PHARMACOGNOSY
Year : 2010  |  Volume : 2  |  Issue : 4  |  Page : 362-364

Enhancement of the norfloxacin antibiotic activity by gaseous Contact with the essential oil of Croton zehntneri


1 Laboratory of Microbiology and Molecular Biology, Center of Biological Sciences and Health, University of the Region of Cariri, Crato (CE), Brazil
2 Laboratory of Research in Natural Products, Center of Biological Sciences and Health, University of the Region of Cariri, Crato (CE), Brazil
3 Laboratory of Genetics of Microrganisms, Department of Molecular Biology, Center of Exacts and Natural Sciences, Federal University of Paraíba, Joăo Pessoa (PB), Brazil

Correspondence Address:
H.D.M. Coutinho
Laboratory of Microbiology and Molecular Biology, Center of Biological Sciences and Health, University of the Region of Cariri, Crato (CE)
Brazil
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DOI: 10.4103/0975-1483.71625

PMID: 21264094

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This is the first on the modulation of norfloxacin antibiotic activity by the volatile compounds of an essential oil. We report the chemical composition and antibiotic modifying activity of the essential oil extracted from the leaves of Croton zehntneri Pax et Hoffm (variety estragole), using the minimal inhibitory dose method and gaseous contact. The leaves of Croton zehntneri Pax et Hoffm (Euphorbiaceae) were subjected to hydrodistillation, and the essential oil extracted was examined with respect to the chemical composition, by gas chromatography-mass spectrometry (GC/MS), and to inhibitory activity of efflux pump by gaseous contact. The main component of the essential oil of C. zehntneri was estragole (76,8%). The gaseous components of the oil enhanced the inhibition zone of norfloxacin in 39,5%. This result shows that this oil influences the antibiotic activity of norfloxacin, possibly affecting the bacterial NorA efflux system, and may be used as an adjuvant in the antibiotic therapy of multidrug resistant pathogens.


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