PHARMACOLOGY
Year : 2010  |  Volume : 2  |  Issue : 4  |  Page : 374-378

In vitro effects of albendazole on Raillietina echinobothrida, the cestode of chicken, Gallus domesticus


Department of Zoology, Pachhunga University College, Mizoram University, Aizawl - 796 001, India

Correspondence Address:
K Lalchhandama
Department of Zoology, Pachhunga University College, Mizoram University, Aizawl - 796 001
India
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DOI: 10.4103/0975-1483.71630

PMID: 21264097

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Albendazole, a member of benzimidazole group of compounds, has been shown to have a broad spectrum activity against all classes of helminth parasites. Although it has also been experimentally proven to be effective against cestode infection of poultry, the actual effects of the drug are not yet described. The present in vitro study demonstrated that the commercial prescription drug Zentel® was significantly effective against adult Raillietina echinobothrida Mégnin, the major cestode parasite of domestic chicken, Gallus domesticus Linnaeus. It clearly exhibited dose-dependent lethal activity at the different concentrations that were tested. Scanning electron microscopy (SEM) revealed that the drug caused extensive structural alterations on the body surface of the cestode. Severe contraction and shrinkage were evident throughout the entire length of the body. The suckers on the scolex became invaginated due to shrinkage. The distinct body segments, the proglottides, were completely distorted. The fine hairy microtriches on the tegument were obliterated and in its place were formed abnormal clumps of tissues. The results of this investigation are in favor of the use of albendazole as a drug of choice in the management of poultry helminthiasis.


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