PHARM CHEMISTRY
Year : 2010  |  Volume : 2  |  Issue : 4  |  Page : 394-398

Synthesis, characterization, and biological evaluation of certain 6-methyl-2(3H)-benzo-1, 3-thiazolyl-1'-ethylidene-2-(o, p- Substituted Acetophenones) hydrazine analogs


1 G.H.G Khalsa College of Pharmacy, Gurusar Sadhar - 141 104, Punjab, India
2 Department of Biotechnology, Punjab University, Chandigarh, India

Correspondence Address:
G Alang
G.H.G Khalsa College of Pharmacy, Gurusar Sadhar - 141 104, Punjab
India
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DOI: 10.4103/0975-1483.71636

PMID: 21264101

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In the present study, five new derivatives (GG4 to GG8) of benzothiazoles were synthesized and evaluated against Staphylococcus aureus (MTCC 737), Pseudomonas aeruginosa (MTCC 424), Escherichia coli (MTCC 1687), and yeast-like fungi Candida tropicalis. p-Toluidine on treatment with ammonium thiocynate formed 2-benzothiazolamines (II), which on reaction with hydrazine hydrate formed a hydrazino derivative (III). Compounds GG4 to GG8 were synthesized by reacting the hydrazine derivative with different acetophenones. All the synthesized compounds were identified by IR and 1 H-NMR, and antimicrobial activity was performed on the synthesized compounds. Presence of NO 2 , Br, OCH 3 , and Cl groups to the substituted benzothiazole enhanced the antibacterial and antifungal activities.


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