PHARM CHEMISTRY
Year : 2010  |  Volume : 2  |  Issue : 4  |  Page : 399-402

Anti-tumor activity of N4 [(E)-1-(2-hydroxyphenyl) methylidene], N4 -[(E)-2-phenylethylidene], N4 [(E,2E)-3-phenyl-2-propenylidene], and N4 [(E)ethylidene] Isonicotinohydrazide on K562 and jurkat cell lines


1 Department of Chemistry, Islamic Azad University, Young Researchers Club, Ardabil, Iran
2 Department of Chemistry, Islamic Azad University, Ardabil, Iran
3 Moravvej Student-Research Institute, Ardabil Branch, Ardabil, Iran
4 Department of Medicinal Sciences, Islamic Azad University, Ardabil, Iran

Correspondence Address:
S Ghammamy
Department of Chemistry, Islamic Azad University, Ardabil
Iran
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DOI: 10.4103/0975-1483.71638

PMID: 21264102

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Using the water eliminated mechanism, reactions of 4-pyridinecarboxylic acid hydrazide and salicylaldehyde, benzaldehyde, cinnamaldehyde, and formaldehyde afforded the corresponding N 4 [(E)-1-(2-hydroxyphenyl) methylidene] (NHPM), N 4 -[(E)-2-phenylethylidene] (NPI), N 4 [(E,2E)-3-phenyl-2-propenylidene] (NPPI), and N 4 [(E) ethylidene] (NEI) isonicotinohydrazide, in high yields, after several minutes, as reported. These new compounds have shown antitumor activity against two kinds of cancer cells, which are K562 (human chronic myeloid leukemia) and Jurkat (human T lymphocyte carcinoma).


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