Year : 2010  |  Volume : 2  |  Issue : 4  |  Page : 424-427

A study on drug-drug interaction of esomeprazole and anti-diabetic drugs

1 Department of Pharmacology, S.C.S. College of Pharmacy, Harapanahalli - 583 131, Karnataka, India
2 College of Clinical Pharmacy, King Faisal University, Alahsa - 31982, Kingdom of Saudi Arabia

Correspondence Address:
R S Setty
College of Clinical Pharmacy, King Faisal University, Alahsa - 31982
Kingdom of Saudi Arabia
Login to access the Email id

DOI: 10.4103/0975-1483.71624

PMID: 21264108

Get Permissions

Drug-drug interaction between esomeprazole at therapeutic and higher doses and sulfonylureas was studied. Sulfonylureas (tolbutamide 40 mg/kg and glibenclamide 40 μg/kg) were administered and the time to onset of hypoglycemia, the duration of the hypoglycemia, and the peak hypoglycemia were determined. Esomeprazole (1.8 mg/kg, 3.6 mg/kg, and 30 mg/kg) was administered for 8 days and its influence on sulfonylurea-induced hypoglycemia was studied. Therapeutic doses of esomeprazole, i.e., 1.8 mg/kg and 3.6 mg/kg dose did not influence the hypoglycemia induced by sulfonylureas. However, a higher dose, i.e., 30 mg/kg, did significantly enhance the duration of hypoglycemia and the peak hypolgycemia. Esomeprazole (30 mg/kg) by itself did not reduce the blood glucose levels; therefore, a pharmacodynamic type of drug interaction can be ruled out. Similarly, a pharmacokinetic type of drug interaction may be ruled out at therapeutic doses. The CYP isoenzyme system involved in the metabolism of sulfonylureas are not very sensitive to esomeprazole and the dose and frequency of administration of sulfonylurea need not be readjusted when they are used concomitantly with esomeprazole (at therapeutic doses).

Print this article     Email this article
Search Again
 Table of Contents
 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Article Access Statistics
 Reader Comments
 Email Alert
 Add to My List
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded14    
    Comments [Add]    

Recommend this journal